| Day | Date | Opponent | Location | TV | Outcome/Time |
| Sat | 08/26/2000 | New Mexico | Lubbock, Texas | | W, 24-3
Recap | Stats | Live Audio |
| Sat | 09/02/2000 | Utah State | Lubbock, Texas | | W, 38-16
Recap | Stats | Live Audio |
| Sat | 09/09/2000 | North Texas | Lubbock, Texas | | W, 13-7
Recap | Stats | Live Audio |
| Sat | 09/16/2000 | Louisiana-Lafayette | Lubbock, Texas | | W, 26-0
Recap | Stats | Live Audio |
| Sat | 09/23/2000 | Open | Open | | All Day
Live Audio |
| Sat | 09/30/2000 | Texas A&M | College Station, Texas | FOX Sports Net | L, 33-15
Recap | Stats | Live Audio |
| Sat | 10/07/2000 | Baylor | Lubbock, Texas
Homecoming | | W, 28-0
Recap | Stats | Live Audio |
| Sat | 10/14/2000 | Nebraska | Lubbock, Texas | FOX Sports Net | L, 56-3
Recap | Stats | Live Audio |
| Sat | 10/21/2000 | Kansas State | Manhattan, Kan. | FOX Sports Net | L, 28-23
Recap | Stats | Live Audio |
| Sat | 10/28/2000 | Kansas | Lawrence, Kan. | | W, 45-39
Recap | Stats | Live Audio |
| Sat | 11/04/2000 | Texas | Lubbock, Texas | FOX Sports Net | L, 29-17
Recap | Stats | Live Audio |
| Sat | 11/11/2000 | Oklahoma State | Lubbock, Texas
Family Day | | W, 58-0
Recap | Stats | Live Audio |
| Sat | 11/18/2000 | Oklahoma | Norman, Okla. | ABC | L, 27-13
Recap | Stats | Live Audio |
| Wed | 12/27/2000 | East Carolina | Houston, Texas
(Galleryfurniture.com Bowl) | ESPN | L, 40-27
Recap | Stats | Archived Audio | FANSlive GameTracker |
