The loss marked Texas Tech's 18th-straight to Missouri as the Tigers now control a 21-11 all-time advantage in the series.
The Red Raiders also dropped to 4-11 all-time in matches played in Columbia.
Tech was hoping to repeat its same magic from last season as the Red Raiders won their first Big 12 match in their sixth league contest against Kansas.
The Red Raiders came into the match a perfect 13-0 when winning the second set. Tech dropped to 2-2 overall in matches that go just four sets.
Tech is now just 1-6 on the year when dropping the opening set. The Red Raiders lone win came against North Texas on Sept. 19.
Missouri's 10 aces marked the most for a Tech opponent this season, surpassing the previous mark of nine set only a few days ago at Texas.
Tech's nine service errors were its most since recording 12 against New Mexico on Sept. 26.
The Red Raiders' .213 hitting percentage was the highest for Tech during Big 12 play this season. It also marked the program's highest average since posting a .314 average at North Texas.
Amanda Dowdy's 22 kills marked her second 20-kill match of the season with the other coming against New Mexico on Sept. 26. Her .293 hitting percentage was her highest since recording a .457 average against North Texas.
Dowdy is now just five kills shy of tying Melissa McGehee (1999-02) for second in the category as she has 1,328 over her career.
Breeann David returned to double-digits in kills after a two-match absence as the freshman finished with 13 overall. David has now been in double-digits in three of Tech's six conference matches.